Performance of retrieved oocytes that mature from metaphase I (MI) to metaphase II (MII) after a GnRH agonist trigger
نویسندگان
چکیده
منابع مشابه
Activation of Akt (protein kinase B) stimulates metaphase I to metaphase II transition in bovine oocytes.
In somatic cells, the serine/threonine kinase Akt (or protein kinase B) was shown to contribute to processes linked to cellular growth, cell survival and cell cycle regulation. In contrast to these findings, the function of Akt during the meiosis of mammalian oocytes remains to be investigated. We analysed the phosphorylation pattern and the activity of Akt during meiotic maturation (transition...
متن کاملClinical benefit of metaphase I oocytes
BACKGROUND We studied the benefit of using in vitro matured metaphase I (MI) oocytes for ICSI in patients with a maximum of 6 mature metaphase II (MII) oocytes at retrieval. METHODS In 2004, 187 ICSI cycles were selected in which maximum 6 MII oocytes and at least one MI oocyte were retrieved. MI oocytes were put in culture to mature until the moment of ICSI, which was performed between 2 to ...
متن کاملAssociation between The Number of Retrieved Mature Oocytes and Insulin Resistance or Sensitivity in Infertile Women Polycystic Ovary Syndrome
Objective The objective of this study was to evaluate LH/FSH and demographic variables on maturation stage of oocytes in patients with polycystic ovary syndrome (PCOS) with or without insulin resistance. MaterialsAndMethods Sixty patients with IVF/ICSI indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20...
متن کاملThe outcome of ICSI of immature MI oocytes and rescued in vitro matured MII oocytes.
BACKGROUND The use of immature oocytes is limited to cases where these are the only available oocytes, and they are usually only microinjected with sperm after having undergone maturation in vitro. This study compares the outcome of injection of sperm into metaphase I oocytes immediately after their denudation (MI) performed 2 h after their retrieval, with the outcome of injection of sperm into...
متن کاملDOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
For the success of fertilization, spindles of vertebrate oocytes must remain stable and correctly organized during the arrest in metaphase II of meiosis. Using a two-hybrid screen with MAPK as a bait, we have recently identified MISS (MAPK interacting and spindle stabilizing) which controls mouse oocyte metaphase II spindle stability. Using the same screen, we identify another MAPK partner, DOC...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2018
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2018.07.881